Unique characteristics of the kinetoplast DNA replication machinery provide potential drug targets in trypanosomatids.
نویسندگان
چکیده
منابع مشابه
Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis
Leishmaniasis is a vector-borne zoonotic disease caused by various species of the genus Leishmania, (trypanosomatidae family) that is transmitted by phlebotomine sandflies. The disease can present in a range of clinical forms, including dermal lesions, metastasis mucocutaneous forms, and fatal visceral forms. In this non-systematic review, we aimed at introducing the role of kinetoplast DNA (kD...
متن کاملMajor therapeutic targets in trypanosomatids
Trypanosomatids are protozoan parasites that have some peculiar characteristics in biological terms, such as the presence of a single flagellum and kinetoplast (i.e., a specialized organelle that concentrates mitochondrial DNA in the parasite) and alternating forms in vectors and hosts with distinct modes of morphology, biochemistry, and exhaust. Among the diseases caused by trypanosomatids are...
متن کاملA nicking enzyme from trypanosomatids which specifically affects the topological linking of duplex DNA circles. Purification and characterization.
Newly replicated duplex DNA minicircles of trypanosomal kinetoplast DNA are nicked in both their monomeric and catenated topological states, whereas mature ones are covalently sealed. The possibility that nicking may play a role during kinetoplast DNA replication by affecting the topological interconversions of monomeric DNA minicircles and catenane networks was studied here in vitro using Crit...
متن کاملPeriodic expression of nuclear and mitochondrial DNA replication genes during the trypanosomatid cell cycle.
In trypanosomatids, DNA replication in the nucleus and in the single mitochondrion (or kinetoplast) initiates nearly simultaneously, suggesting that the DNA synthesis (S) phases of the nucleus and the mitochondrion are coordinately regulated. To investigate the basis for the temporal link between nuclear and mitochondrial DNA synthesis phases the expression of the genes encoding DNA ligase I, t...
متن کاملBinding of the universal minicircle sequence binding protein at the kinetoplast DNA replication origin.
Kinetoplast DNA, the mitochondrial DNA of trypanosomatids, is a remarkable DNA structure that contains, in the species Crithidia fasciculata, 5000 topologically linked duplex DNA minicircles. Their replication initiates at two conserved sequences, a dodecamer, known as the universal minicircle sequence (UMS), and a hexamer, which are located at the replication origins of the minicircle L and H ...
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ورودعنوان ژورنال:
- Advances in experimental medicine and biology
دوره 625 شماره
صفحات -
تاریخ انتشار 2008